Mice carrying a CD20 gene disruption

  title={Mice carrying a CD20 gene disruption},
  author={Theresa L. O’Keefe and Gareth T. Williams and Sarah L. Davies and Michael Neuberger},
 CD20 is a hallmark antigen of B lymphocytes. Its expression is restricted to precursor and mature B cells but it is not expressed on plasma cells. The protein is a membrane-embedded phosphoprotein that appears likely to transverse the membrane four times. Its function is unknown although CD20 has been variously proposed to play a role in B-cell activation, proliferation, and calcium transport. A unique homologue of human CD20 has been described in mouse, which also shows a B-cell-specific… CONTINUE READING
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Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes

  • J. K. Bubien, Zhou, L.-J, P. D. Bell, R. A. Frizzell, F. Tedder
  • J Cell Biol
  • 1993
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