Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist

@article{Meirsman2016MiceLG,
  title={Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist},
  author={Aura Carole Meirsman and Julie Le Merrer and Lucie P Pellissier and Jorge Diaz and J{\'e}r{\^o}me A J Becker},
  journal={Biological Psychiatry},
  year={2016},
  volume={79},
  pages={917-927}
}
  • Aura Carole Meirsman, Julie Le Merrer, +2 authors Jérôme A J Becker
  • Published in Biological Psychiatry 2016
  • Psychology, Medicine
  • BACKGROUND GPR88 is an orphan G protein coupled receptor highly enriched in the striatum, and previous studies have focused on GPR88 function in striatal physiology. The receptor is also expressed in other brain areas, and here we examined whether GPR88 function extends beyond striatal-mediated responses. METHODS We created Gpr88 knockout mice and examined both striatal and extrastriatal regions at molecular and cellular levels. We also tested striatum-, hippocampus-, and amygdala-dependent… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 19 CITATIONS

    Lack of anticipatory behavior in Gpr88 knockout mice showed by automatized home cage phenotyping

    VIEW 10 EXCERPTS
    CITES METHODS, BACKGROUND & RESULTS
    HIGHLY INFLUENCED