Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System

  title={Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System},
  author={Asa Abeliovich and Yvonne Schmitz and Isabel Fari{\~n}as and Derek L. Choi-Lundberg and W B Ho and Pablo E Castillo and Natasha Shinsky and Jos{\'e} Manuel Garc{\'i}a Verdugo and Mark P. Armanini and Anne L Ryan and Mary Hynes and Heidi Phillips and David Sulzer and Arnon Rosenthal},
The subcellular localization 46100 Burjasot of the synucleins has not been established definitively, Spain and suggested sites of action include the presynaptic 3 Although its physiological activity remains unclear, Summary ␣-Syn has been implicated in the etiology of two common neurodegenerative disorders, Alzheimer's disease ␣-Synuclein (␣-Syn) is a 14 kDa protein of unknown (AD) and Parkinson's disease (PD). The pathological function that has been implicated in the pathophysiol-hallmark of… CONTINUE READING


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