Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System

@article{Abeliovich2000MiceL,
  title={Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System},
  author={Asa Abeliovich and Yvonne Schmitz and Isabel Fari{\~n}as and Derek L. Choi-Lundberg and W B Ho and Pablo E Castillo and Natasha Shinsky and Jos{\'e} Manuel Garc{\'i}a Verdugo and Mark P. Armanini and Anne L Ryan and Mary Hynes and Heidi Phillips and David Sulzer and Arnon Rosenthal},
  journal={Neuron},
  year={2000},
  volume={25},
  pages={239-252}
}
The subcellular localization 46100 Burjasot of the synucleins has not been established definitively, Spain and suggested sites of action include the presynaptic 3 Although its physiological activity remains unclear, Summary ␣-Syn has been implicated in the etiology of two common neurodegenerative disorders, Alzheimer's disease ␣-Synuclein (␣-Syn) is a 14 kDa protein of unknown (AD) and Parkinson's disease (PD). The pathological function that has been implicated in the pathophysiol-hallmark of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 121 extracted citations

α-Synuclein binds the K(ATP) channel at insulin-secretory granules and inhibits insulin secretion.

American journal of physiology. Endocrinology and metabolism • 2011
View 5 Excerpts
Highly Influenced

Alpha-Synuclein Loss in Spinal Muscular Atrophy

Journal of Molecular Neuroscience • 2010
View 4 Excerpts
Highly Influenced

New Developments in Genetic rat models of Parkinson's Disease.

Movement disorders : official journal of the Movement Disorder Society • 2018
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 54 references

Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1998
View 4 Excerpts
Highly Influenced

Ala 30 Pro intranuclear inclusions and dystrophic neurites in brain . Science mutation in the gene encoding a - synuclein in Parkinson ’ s disease . 277 , 1990 – 1993

H. Przuntek, J. T. Epplen, L. Schöls, O. Riess
Nat . Genet . • 1998

Calcium dependence and Lavedan , C . ( 1998 ) . The synuclein family

J. S. Dittman, W. G. Regehr
Genome Res . • 1998
View 1 Excerpt

Similar Papers

Loading similar papers…