Mic1-3 Knockout Toxoplasma gondii is a good candidate for a vaccine against T. gondii-induced abortion in sheep

@inproceedings{Mevelec2010Mic13KT,
  title={Mic1-3 Knockout Toxoplasma gondii is a good candidate for a vaccine against T. gondii-induced abortion in sheep},
  author={M F Mevelec and C{\'e}line Ducournau and Alaa Bassuny Ismael and Michel Olivier and {\'E}douard S{\`e}che and Maryse Lebrun and Daniel T. Bout and Isabelle H. Dimier-Poisson},
  booktitle={Veterinary research},
  year={2010}
}
This study assessed the effectiveness of a mutant strain of Toxoplasma gondii (RH strain) lacking the mic1 and mic3 genes (Mic1-3KO) against Toxoplasma abortion in sheep. Ewes were inoculated subcutaneously with 10(5) Mic1-3KO tachyzoïtes in three independent experiments. Following vaccination, Mic1-3KO induced a mild febrile response and serum IgG antibodies, which persisted throughout the experiments. Tissue cysts formed in the sheep, but were not, under our experimental conditions… CONTINUE READING

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