Mianserin: A Review of its Pharmacological Properties and Therapeutic Efficacy in Depressive Illness

@article{Brogden1978MianserinAR,
  title={Mianserin: A Review of its Pharmacological Properties and Therapeutic Efficacy in Depressive Illness},
  author={Rex N. Brogden and R. C. Heel and T. M. Speight and Gayle C. Avery},
  journal={Drugs},
  year={1978},
  volume={16},
  pages={273-301}
}
Synopsis: Mianserin1 is a tetracyclic compound advocated for the treatment of depressive illness and depression associated with anxiety. It combines antidepressant activity with a sedative effect and has an EEG and clinical activity profile similar to that of amitriptyline. It has an overall efficacy comparable with amitriptyline and imipramine in depressive illness, but at dosages which have achieved a similar overall clinical improvement, mianserin causes significantly fewer anticholinergic… CONTINUE READING

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Some cardiovascular actions of mianserin in anaesthetised dogs (unpublished data

B. Engel, L. B. Cobbin
Organon • 1978

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