Mia40 Protein Serves as an Electron Sink in the Mia40-Erv1 Import Pathway*

@article{Neal2015Mia40PS,
  title={Mia40 Protein Serves as an Electron Sink in the Mia40-Erv1 Import Pathway*},
  author={Sonya E. Neal and Deepa V. Dabir and H. Tienson and D. Horn and Kathrin Glaeser and Rachel R Ogozalek Loo and A. Barrientos and C. Koehler},
  journal={The Journal of Biological Chemistry},
  year={2015},
  volume={290},
  pages={20804 - 20814}
}
Background: Oxidized substrates such as Tim13 acquire two disulfide bonds simultaneously, but Mia40 has one active redox center that accepts two electrons. Results: Mia40 can acquire up to six electrons when oxidizing substrates. Conclusion: Mia40 has the flexibility to accept several electrons. Significance: Mechanistic properties of the MIA pathway are unique compared with redox pathways in the endoplasmic reticulum and bacterial periplasm. A redox-regulated import pathway consisting of Mia40… Expand
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