MiTF links Erk1/2 kinase and p21 activation after UVC radiation in normal human melanocytes and melanoma cells

@inproceedings{Liu2010MiTFLE,
  title={MiTF links Erk1/2 kinase and p21 activation after UVC radiation in normal human melanocytes and melanoma cells},
  author={Feng Liu and Amarinder Singh and Zhen Yang and Angela M Gomez Garcia and Yu Kong and Frank L. Meyskens},
  year={2010}
}
As a survival factor for melanocytes lineage cells, MiTF plays multiple roles in development and melanomagenesis. What role MiTF plays in the DNA damage response is currently unknown. In this report we observed that MiTF was phosphorylated at serine 73 after UVC radiation, which was followed by proteasome-mediated degradation. Unlike after c-Kit stimulation, inhibiting p90RSK-1 did not abolish the band shift of MiTF protein, nor did it abolish the UVC-mediated MiTF degradation, suggesting that… CONTINUE READING
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