MiRduplexSVM: A High-Performing MiRNA-Duplex Prediction and Evaluation Methodology

@inproceedings{Karathanasis2015MiRduplexSVMAH,
  title={MiRduplexSVM: A High-Performing MiRNA-Duplex Prediction and Evaluation Methodology},
  author={Nestoras Karathanasis and Ioannis Tsamardinos and P. Poirazi},
  booktitle={PloS one},
  year={2015}
}
We address the problem of predicting the position of a miRNA duplex on a microRNA hairpin via the development and application of a novel SVM-based methodology. Our method combines a unique problem representation and an unbiased optimization protocol to learn from mirBase19.0 an accurate predictive model, termed MiRduplexSVM. This is the first model that provides precise information about all four ends of the miRNA duplex. We show that (a) our method outperforms four state-of-the-art tools… CONTINUE READING
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