MiRNA-621 sensitizes breast cancer to chemotherapy by suppressing FBXO11 and enhancing p53 activity

@inproceedings{Xue2016MiRNA621SB,
  title={MiRNA-621 sensitizes breast cancer to chemotherapy by suppressing FBXO11 and enhancing p53 activity},
  author={Jingyan Xue and Yudan Chi and Yu Zong Chen and Shujia Huang and Xingwang Ye and Jiangong Niu and Wen-jia Wang and Lawrence M Pfeffer and Z-m Shao and Z-H Wu and Jianghong Wu},
  booktitle={Oncogene},
  year={2016}
}
MicroRNAs (miRNAs) have been demonstrated to have critical roles in regulating cancer cell proliferation, survival and sensitivity to chemotherapy. The potential application of using miRNAs to predict therapeutic response to cancer treatment holds high promise, but miRNAs with predictive value remain to be identified and underlying mechanisms have not been completely understood. Here, we show a strong correlation between miR-621 expression and chemosensitivity to paclitaxel plus carboplatin… CONTINUE READING
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