MiRNA-335 suppresses neuroblastoma cell invasiveness by direct targeting of multiple genes from the non-canonical TGF-β signalling pathway.

@article{Lynch2012MiRNA335SN,
  title={MiRNA-335 suppresses neuroblastoma cell invasiveness by direct targeting of multiple genes from the non-canonical TGF-β signalling pathway.},
  author={Jennifer L. Lynch and Joanna Fay and Maria H. Meehan and K. M. G. Bryan and Karen M Watters and Derek M. Murphy and Raymond L. Stallings},
  journal={Carcinogenesis},
  year={2012},
  volume={33 5},
  pages={976-85}
}
Transforming growth factor-β (TGF-β) signaling regulates many diverse cellular activities through both canonical (SMAD-dependent) and non-canonical branches, which includes the mitogen-activated protein kinase (MAPK), Rho-like guanosine triphosphatase and phosphatidylinositol-3-kinase/AKT pathways. Here, we demonstrate that miR-335 directly targets and downregulates genes in the TGF-β non-canonical pathways, including the Rho-associated coiled-coil containing protein (ROCK1) and MAPK1… CONTINUE READING

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