MiRNA-30a-mediated autophagy inhibition sensitizes renal cell carcinoma cells to sorafenib.

  title={MiRNA-30a-mediated autophagy inhibition sensitizes renal cell carcinoma cells to sorafenib.},
  author={Bing Qing Zheng and Hua Zhu and Donghua Gu and Xiaodong Pan and Lin Qian and Bo-xin Xue and Dongrong Yang and Jundong Zhou and Yuxi Shan},
  journal={Biochemical and biophysical research communications},
  volume={459 2},
Chemotherapy-induced autophagy activation often contributes to cancer resistance. MiRNA-30a (miR-30a) is a potent inhibitor of autophagy by downregulating Beclin-1. In this study, we characterized the role of miR-30a in sorafenib-induced activity in renal cell carcinoma (RCC) cells. We found that expression of miR-30a was significantly downregulated in several human RCC tissues and in RCC cell lines. Accordingly, its targeted gene Beclin-1 was upregulated. Sorafenib activated autophagy in RCC… CONTINUE READING
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