MiR-96 downregulates REV1 and RAD51 to promote cellular sensitivity to cisplatin and PARP inhibition.

@article{Wang2012MiR96DR,
  title={MiR-96 downregulates REV1 and RAD51 to promote cellular sensitivity to cisplatin and PARP inhibition.},
  author={Yemin Wang and Jen-Wei Huang and Philamer C Calses and Christopher J. Kemp and Toshiyasu Taniguchi},
  journal={Cancer research},
  year={2012},
  volume={72 16},
  pages={4037-46}
}
Cell survival after DNA damage relies on DNA repair, the abrogation of which causes genomic instability. The DNA repair protein RAD51 and the trans-lesion synthesis DNA polymerase REV1 are required for resistance to DNA interstrand cross-linking agents such as cisplatin. In this study, we show that overexpression of miR-96 in human cancer cells reduces the levels of RAD51 and REV1 and impacts the cellular response to agents that cause DNA damage. MiR-96 directly targeted the coding region of… CONTINUE READING