MiR-874 inhibits metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma by targeting SOX12.

@article{Jiang2017MiR874IM,
  title={MiR-874 inhibits metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma by targeting SOX12.},
  author={Tao Jiang and Lian-Yue Guan and Yan-Shuo Ye and H L Liu and Rui Li},
  journal={American journal of cancer research},
  year={2017},
  volume={7 6},
  pages={1310-1321}
}
MicroRNA-874 (miR-874), a novel cancer-associated microRNA (miRNA), has been reported to play a suppressive role in multiple malignancies. However, its function in cell migration and invasion in hepatocellular carcinoma (HCC) and the mechanisms responsible remain unclear. Here, we found miR-874 to be significantly downregulated in HCC tissues and cell lines. Moreover, this decreased expression strongly correlated with clinical stage and lymph node metastasis. Accordingly, ectopic expression of… CONTINUE READING

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