MiR-7, miR-9 and miR-375 contribute to effect of Exendin-4 on pancreatic β-cells in high-fat-diet-fed mice.

@article{Guo2018MiR7MA,
  title={MiR-7, miR-9 and miR-375 contribute to effect of Exendin-4 on pancreatic β-cells in high-fat-diet-fed mice.},
  author={Chang Fa Guo and Yi-Qiong Sun and Qiang Hua Li and Jin-chao Zhang},
  journal={Clinical and investigative medicine. Medecine clinique et experimentale},
  year={2018},
  volume={41 1},
  pages={
          E16-E24
        }
}
PURPOSE The purpose of this study was to test whether glucagon-like peptide-1 (GLP-1) receptor activation preserved pancreatic β-cells via the regulation of microRNAs and target genes in high-fat-diet-fed mice. METHODS C57BL/6 male mice were simultaneously treated with high-fat-diet (HFD) and GLP-1 analogue, Exendin-4 (Ex-4) (3 μg/kg/day or 30 μg/kg/day), i.p. or vehicle, for consecutive 13 weeks. Fasting blood glucose, postprandial blood glucose, ΔI30/ΔG30, HOMA-IR and HOMA-% β were measured… CONTINUE READING
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