MiR-7, inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the EMT of breast cancer stem cells by downregulating the STAT3 pathway.

@article{Zhang2014MiR7II,
  title={MiR-7, inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the EMT of breast cancer stem cells by downregulating the STAT3 pathway.},
  author={Hongyi Zhang and Kai Yong Cai and Jing Wang and Xiaoying Wang and Kai Cheng and Fangfang Shi and Longwei Jiang and Yunxia Zhang and Jun Dou},
  journal={Stem cells},
  year={2014},
  volume={32 11},
  pages={2858-68}
}
Epithelial-mesenchymal transition (EMT) contributes to tumor invasion and metastasis in many cancers and correlates highly with the acquisition of cancer stem cell (CSC) characteristics. EMT also correlates with changes in specific microRNAs (miRNAs) that have already been integrated into tumorigenic programs as either oncogenes or tumor suppressor genes… CONTINUE READING