MiR-499 Regulates Cell Proliferation and Apoptosis during Late-Stage Cardiac Differentiation via Sox6 and Cyclin D1

@inproceedings{Li2013MiR499RC,
  title={MiR-499 Regulates Cell Proliferation and Apoptosis during Late-Stage Cardiac Differentiation via Sox6 and Cyclin D1},
  author={Xianhui Li and Jiaji Wang and Zhuqing Jia and Qinghua Cui and Chenguang Zhang and Weiping Wang and Ping Chen and Kangtao Ma and Chunyan Zhou},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND MiR-499 is a cardiac-abundant miRNA. However, the biological functions of miR-499 in differentiated cardiomyocytes or in the cardiomyocyte differentiation process is not very clear. Sox6 is believed to be one of its targets, and is also believed to play a role in cardiac differentiation. Therefore, our aim was to investigate the association between Sox6 and miR-499 during cardiac differentiation. METHODOLOGY/PRINCIPAL FINDINGS Using a well-established in vitro cardiomyocyte… CONTINUE READING
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