MiR-497 decreases cisplatin resistance in ovarian cancer cells by targeting mTOR/P70S6K1

Abstract

The mechanism of cisplatin resistance in ovarian cancer is not clearly understood. In the present investigation, we found that the expression levels of miR-497 were reduced in chemotherapy-resistant ovarian cancer cells and tumor tissues due to hypermethylation of miR-497 promoter. Low miR-497 expression levels were associated with chemo-resistant phonotype… (More)
DOI: 10.18632/oncotarget.4762

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