MiR-433 mediates ERRγ-suppressed osteoblast differentiation via direct targeting to Runx2 mRNA in C3H10T1/2 cells.

@article{Kim2013MiR433ME,
  title={MiR-433 mediates ERRγ-suppressed osteoblast differentiation via direct targeting to Runx2 mRNA in C3H10T1/2 cells.},
  author={Eun-Jung Kim and I Kang and Jeong Woong Lee and Won-Gu Jang and Jeong-Tae Koh},
  journal={Life sciences},
  year={2013},
  volume={92 10},
  pages={562-8}
}
AIMS MicroRNAs (miRNA) are involved in various biological processes including cellular differentiation. However, the role of miR-433 in osteoblast differentiation remains poorly understood. The objective of this study was to investigate the effect of miR-433 on BMP2-induced osteoblast differentiation. MAIN METHODS The expression of mature miR-433 in cells was detected by real-time PCR. RT-PCR or real-time PCR was used to confirm the expression of osteogenic genes. For the activation or… CONTINUE READING