MiR-378 controls cardiac hypertrophy by combined repression of mitogen-activated protein kinase pathway factors.

@article{Ganesan2013MiR378CC,
  title={MiR-378 controls cardiac hypertrophy by combined repression of mitogen-activated protein kinase pathway factors.},
  author={Jayavarshni Ganesan and Deepak Ramanujam and Yassine Sassi and Andrea Ahles and Claudia Jentzsch and Stanislas Werfel and Simon Leierseder and Xavier Loyer and Mauro Giacca and Lorena Zentilin and Thomas Thum and Bernhard Laggerbauer and Stefan Engelhardt},
  journal={Circulation},
  year={2013},
  volume={127 21},
  pages={
          2097-106
        }
}
BACKGROUND Several microRNAs (miRs) have been shown to regulate gene expression in the heart, and dysregulation of their expression has been linked to cardiac disease. miR-378 is strongly expressed in the mammalian heart but so far has been studied predominantly in cancer, in which it regulates cell survival and tumor growth. METHODS AND RESULTS Here, we report tight control of cardiomyocyte hypertrophy through miR-378. In isolated primary cardiomyocytes, miR-378 was found to be both… CONTINUE READING
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