MiR-373 targeting of the Rab22a oncogene suppresses tumor invasion and metastasis in ovarian cancer

@inproceedings{Zhang2014MiR373TO,
  title={MiR-373 targeting of the Rab22a oncogene suppresses tumor invasion and metastasis in ovarian cancer},
  author={Yue Zhang and Fu-jun Zhao and Li-Lan Chen and Luo-Qiao Wang and Kenneth P. Nephew and Yingli Wu and Shu X Zhang},
  booktitle={Oncotarget},
  year={2014}
}
Metastasis is major cause of mortality in patients with ovarian cancer. MiR-373 has been shown to play pivotal roles in tumorigenesis and metastasis; however, a role for miR-373 in ovarian cancer has not been investigated. In this study, we show that the miR-373 expression is down-regulated in human epithelial ovarian cancer (EOC) and inversely correlated with clinical stage and histological grade. Ectopic overexpression of miR-373 in human EOC cells suppressed cell invasion in vitro and… CONTINUE READING
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The Role of microRNAs in the Tumorigenesis of Ovarian Cancer

G DiLeva, CM Croce
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