MiR-34a Targeting of Notch Ligand Delta-Like 1 Impairs CD15+/CD133+ Tumor-Propagating Cells and Supports Neural Differentiation in Medulloblastoma

@inproceedings{Antonellis2011MiR34aTO,
  title={MiR-34a Targeting of Notch Ligand Delta-Like 1 Impairs CD15+/CD133+ Tumor-Propagating Cells and Supports Neural Differentiation in Medulloblastoma},
  author={Pasqualino de Antonellis and Chiara Medaglia and Emilio Cusanelli and Immacolata Andolfo and Lucia Liguori and Gennaro De Vita and Marianeve Carotenuto and Annamaria Bello and Fabio Formiggini and Aldo Galeone and Giuseppe De Rosa and Antonella Virgilio and Immacolata Scognamiglio and Manuela Sciro and Giuseppe Basso and Johannes Hubertus Schulte and Giuseppe Cinalli and Achille Iolascon and Massimo Zollo},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Through negative regulation of gene expression, microRNAs (miRNAs) can function as oncosuppressors in cancers, and can themselves show altered expression in various tumor types. Here, we have investigated medulloblastoma tumors (MBs), which arise from an early impairment of developmental processes in the cerebellum, where Notch signaling is involved in many of the cell-fate-determining stages. Notch regulates a subset of MB cells that have stem-cell-like properties and can promote… CONTINUE READING
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