MiR-338 controls BPA-triggered pancreatic islet insulin secretory dysfunction from compensation to decompensation by targeting Pdx-1.

@article{Wei2017MiR338CB,
  title={MiR-338 controls BPA-triggered pancreatic islet insulin secretory dysfunction from compensation to decompensation by targeting Pdx-1.},
  author={Jie Wei and Dongxiao Ding and Tao Wang and Qiong Liu and Yi Lin},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2017},
  volume={31 12},
  pages={5184-5195}
}
Bisphenol A (BPA) can disrupt glucose homeostasis and impair pancreatic islet function; however, the mechanisms behind these effects are poorly understood. Male mice (4 wk old) were treated with BPA (50 or 500 μg/kg/d) for 8 wk. Whole-body glucose homeostasis, pancreatic islet morphology and function, and miR-338-mediated molecular signal transduction analyses were examined. We showed that BPA treatment led to a disruption of glucose tolerance and a compensatory increase of pancreatic islets… CONTINUE READING

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