MiR-320a acts as a prognostic factor and Inhibits metastasis of salivary adenoid cystic carcinoma by targeting ITGB3

@article{Sun2015MiR320aAA,
  title={MiR-320a acts as a prognostic factor and Inhibits metastasis of salivary adenoid cystic carcinoma by targeting ITGB3},
  author={Li-juan Sun and Bodu Liu and Zhao-yu Lin and Yandan Yao and Yanyang Chen and Y. Li and Jianing Chen and Dongsheng Yu and Zhangui Tang and B. Wang and Shuguang Zeng and S. Fan and Youyuan Wang and Yilin Li and E. Song and Jinsong Li},
  journal={Molecular Cancer},
  year={2015},
  volume={14}
}
BackgroundSalivary Adenoid cystic carcinoma (SACC) patients with local invasion and lung metastasis are often resistant to conventional therapy such as operation, chemotherapy and radiotherapy. To explore the underling mechanisms, we studied the roles of miRNA in regulating invasiveness of SACC cells.MethodsMicroRNA profiling was done in SACC cells with microarray. MiRNA mimics or antisense oligonucleotide was transfected and invasiveness of SACC cells was evaluated by adhesion assay and… Expand
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TLDR
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References

SHOWING 1-10 OF 47 REFERENCES
MCRS1 overexpression, which is specifically inhibited by miR-129*, promotes the epithelial-mesenchymal transition and metastasis in non-small cell lung cancer
TLDR
It is observed that an overexpression of microspherule protein 1 (MCRS1) promotes the invasion and metastasis of non-small cell lung cancer (NSCLC) cells, and systematic investigations showed that MCRS1 was directly and negatively regulated by the binding of miR-129* to its 3’-UTR, which provides a new angle in understanding the basis for the invasion of lung cancer. Expand
MiR-21 Indicates Poor Prognosis in Tongue Squamous Cell Carcinomas as an Apoptosis Inhibitor
Purpose: We aim to examine miR-21 expression in tongue squamous cell carcinomas (TSCC) and correlate it with patient clinical status, and to investigate its contribution to TSCC cell growth,Expand
MicroRNA Profiling of Salivary Adenoid Cystic Carcinoma: Association of miR-17-92 Upregulation with Poor Outcome
TLDR
It is indicated that the upregulation of miR-17-92 may play a role in the biology of ACC and could be potentially targeted in future therapeutic studies. Expand
Expression of c-kit and Slug correlates with invasion and metastasis of salivary adenoid cystic carcinoma.
TLDR
Findings indicated that c-kit/Slug pathway might participate in the invasion and metastasis of salivary ACC. Expand
[Corrigendum] MicroRNA-320a inhibits tumor invasion by targeting neuropilin 1 and is associated with liver metastasis in colorectal cancer.
TLDR
It is suggested that miR-320a may be a novel therapeutic candidate for the treatment of colorectal cancer and useful for identifying CRC patients that are at an elevated risk for developing liver metastasis. Expand
microRNA-320a inhibits tumor invasion by targeting neuropilin 1 and is associated with liver metastasis in colorectal cancer.
TLDR
It is demonstrated that miR-320a may be useful for identifying CRC patients that are at an elevated risk for developing liver metastasis, and that it may be a novel therapeutic candidate for the treatment of colorectal cancer. Expand
MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1
TLDR
Stable chemotherapy-resistant tongue squamous cell carcinoma cell lines are established by exposing the parental CAL27 and SCC25 lines to escalating concentrations of cisplatin for 6 months and it is suggested that reduced expression of miR-200b and miB-15b underscores the mechanisms of chemotherapy-induced EMT in TSCC, and may serve as therapeutic targets to reverse chemotherapy resistance in tongue cancers. Expand
Microrna 130b Suppresses Migration and Invasion of Colorectal Cancer Cells through Downregulation of Integrin β1
TLDR
Data demonstrate that miR-130b downregulates its target-integrin β1, leading to the impaired migration and invasion of CRC cells. Expand
MicroRNA-320a suppresses human colon cancer cell proliferation by directly targeting β-catenin.
TLDR
The findings indicate that miR-320a suppresses the growth of colon cancer cells by directly targeting β-catenin, suggesting its application in prognosis prediction and cancer treatment. Expand
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
TLDR
It is proposed that ZEB1 links EMT-activation and stemness-maintenance by suppressingstemness-inhibiting microRNAs (miRNAs) and thereby is a promoter of mobile, migrating cancer stem cells. Expand
...
1
2
3
4
5
...