MiR-30b Attenuates Neuropathic Pain by Regulating Voltage-Gated Sodium Channel Nav1.3 in Rats

@inproceedings{Su2017MiR30bAN,
  title={MiR-30b Attenuates Neuropathic Pain by Regulating Voltage-Gated Sodium Channel Nav1.3 in Rats},
  author={Songxue Su and Jinping Shao and Qingzan Zhao and Xiuhua Ren and Weihua Cai and Lei Erbao Li and Qian Bai and Xuemei Chen and Bo Xu and Jian Wang and Jing Cao and Weidong Zang},
  booktitle={Front. Mol. Neurosci.},
  year={2017}
}
Nav1.3 is a tetrodotoxin-sensitive isoform among voltage-gated sodium channels that are closely associated with neuropathic pain. It can be up-regulated following nerve injury, but its biological function remains uncertain. MicroRNAs (miRNAs) are endogenous non-coding RNAs that can regulate post-transcriptional gene expression by binding with their target mRNAs. Using Target Scan software, we discovered that SCN3A is the major target of miR-30b, and we then determined whether miR-30b regulated… CONTINUE READING