MiR-30a regulates the proliferation, migration, and invasion of human osteosarcoma by targeting Runx2

@article{Zhang2015MiR30aRT,
  title={MiR-30a regulates the proliferation, migration, and invasion of human osteosarcoma by targeting Runx2},
  author={Ruyi Zhang and Shujuan Yan and Jing Wang and Fang Deng and Yangliu Guo and Ya Li and Mengtian Fan and Qilin Song and Hongxia Liu and Yaguang Weng and Qiong Shi},
  journal={Tumor Biology},
  year={2015},
  volume={37},
  pages={3479-3488}
}
Osteosarcoma (OS) is the most common primary malignant bone tumor in young patients. However, treatment paradigms and survival rates have not improved in decades. MicroRNAs have been shown to be critical regulators of physiological homeostasis and pathological process, including bone disease. Nearly half of the microRNA (miRNA) genes are located at genomic regions and fragile sites known to be frequently deleted or amplified in various kinds of cancers. In this study, we investigated the role… CONTINUE READING