MiR-30a inhibits Th17 differentiation and demyelination of EAE mice by targeting the IL-21R

@article{Qu2016MiR30aIT,
  title={MiR-30a inhibits Th17 differentiation and demyelination of EAE mice by targeting the IL-21R},
  author={Xuebin Qu and Jun Zhou and Ting Wang and Jingjing Han and Ruiqin Yao},
  journal={Brain, Behavior, and Immunity},
  year={2016},
  volume={57},
  pages={193-199}
}
T helper cells 17 (Th17) are recognized as key participants in the pathogenesis of chronic autoimmune diseases such as multiple sclerosis (MS). Regulation of Th17 differentiation is a valuable strategy for diagnosis and treatment of these complicated immune disorders. Here, by genome-wide expression profiling of microRNAs (miRs), we screened miR-30a, whose level was greatly decreased during Th17 differentiation and the process of demyelination disease, both in MS patients and experimental… CONTINUE READING
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