MiR-24 Is Required for Hematopoietic Differentiation of Mouse Embryonic Stem Cells

@inproceedings{Roy2015MiR24IR,
  title={MiR-24 Is Required for Hematopoietic Differentiation of Mouse Embryonic Stem Cells},
  author={Lynn Roy and Emmanuel Bikorimana and Danica Lapid and Hyewon Park Choi and Tan Thanh Nguyen and Richard Dahl},
  booktitle={PLoS genetics},
  year={2015}
}
Overexpression of miRNA, miR-24, in mouse hematopoietic progenitors increases monocytic/ granulocytic differentiation and inhibits B cell development. To determine if endogenous miR-24 is required for hematopoiesis, we antagonized miR-24 in mouse embryonic stem cells (ESCs) and performed in vitro differentiations. Suppression of miR-24 resulted in an inability to produce blood and hematopoietic progenitors (HPCs) from ESCs. The phenotype is not a general defect in mesoderm production since we… CONTINUE READING
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