MiR-223 Suppresses Cell Proliferation by Targeting IGF-1R

@article{Jia2011MiR223SC,
  title={MiR-223 Suppresses Cell Proliferation by Targeting IGF-1R},
  author={Cheng You Jia and H. Li and Xuye Zhu and Y. Dong and D. Fu and Q. Zhao and Wei Wu and X. Z. Wu},
  journal={PLoS ONE},
  year={2011},
  volume={6}
}
To study the roles of microRNA-223 (miR-223) in regulation of cell growth, we established a miR-223 over-expression model in HeLa cells infected with miR-223 by Lentivirus pLL3.7 system. We observed in this model that miR-223 significantly suppressed the proliferation, growth rate, colony formation of HeLa cells in vitro, and in vivo tumorigenicity or tumor formation in nude mice. To investigate the mechanisms involved, we scanned and examined the potential and putative target molecules of miR… Expand
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