MiR-221 promotes cardiac hypertrophy in vitro through the modulation of p27 expression.

@article{Wang2012MiR221PC,
  title={MiR-221 promotes cardiac hypertrophy in vitro through the modulation of p27 expression.},
  author={Changxin Wang and Shuiyun Wang and Peng Zhao and Xiaojian Wang and Jizheng Wang and Yilu Wang and Lei Song and Yubao Zou and Rutai Hui},
  journal={Journal of cellular biochemistry},
  year={2012},
  volume={113 6},
  pages={2040-6}
}
Cardiac hypertrophy has been known as an independent predictor for cardiovascular morbidity and mortality. Molecular mechanisms underlying the development of heart failure remain elusive. Recently, microRNAs (miRs) have been established as important regulators in cardiac hypertrophy. Here, we reported miR-221 was up-regulated in both transverse aortic constricted mice and patients with hypertrophic cardiomyopathy (HCM). Forced expression of miR-221 by transfection of miR-221 mimics increased… CONTINUE READING
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