MiR-22-silenced cyclin A expression in colon and liver cancer cells is regulated by bile acid receptor.

@article{Yang2015MiR22silencedCA,
  title={MiR-22-silenced cyclin A expression in colon and liver cancer cells is regulated by bile acid receptor.},
  author={Fan Yang and Ying Hu and Hui-Xin Liu and Yu-Jui Yvonne Wan},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 10},
  pages={
          6507-15
        }
}
Because of the significant tumor-suppressive role of microRNA-22 (miR-22), the current study was designed to understand the regulation of miR-22 and to identify additional downstream miR-22 targets in liver and colon cells. The data showed that miR-22 was transcriptionally regulated by bile acid receptor farnesoid X receptor (FXR) through direct binding to an invert repeat 1 motif located at -1012 to -1025 bp upstream from miR-22. Among the studied primary and secondary bile acids… CONTINUE READING
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