MiR-212-3p inhibits LPS-induced inflammatory response through targeting HMGB1 in murine macrophages.

@article{Chen2017MiR2123pIL,
  title={MiR-212-3p inhibits LPS-induced inflammatory response through targeting HMGB1 in murine macrophages.},
  author={Weiwei Chen and Xiaoying Ma and Peng Zhang and Qifeng Li and Xin Liang and Jian Liu},
  journal={Experimental cell research},
  year={2017},
  volume={350 2},
  pages={318-326}
}
Sepsis is a major cause of mortality in seriously ill patients characterized by a series of severe systemic inflammatory responses due to an infection. Thus, there is a critically need to search more accurate biomarkers and targets for diagnosis and treatment of sepsis. Our study showed that miR-212-3p was up-regulated in LPS-treated macrophage RAW264.7 cells. Overexpression of miR-212-3p in RAW264.7 cells led to suppression of pro-inflammatory cytokines (TNF-α and IL-6) induced by LPS… CONTINUE READING