MiR-21 suppresses endothelial progenitor cell proliferation by activating the TGFβ signaling pathway via downregulation of WWP1.

@article{Zuo2015MiR21SE,
  title={MiR-21 suppresses endothelial progenitor cell proliferation by activating the TGFβ signaling pathway via downregulation of WWP1.},
  author={Keqiang Zuo and Maoquan Li and Xiaoping Zhang and Chenghui Lu and Shi Wang and Kangkang Zhi and Bin He},
  journal={International journal of clinical and experimental pathology},
  year={2015},
  volume={8 1},
  pages={414-22}
}
Endothelial damage is strongly associated with cardiovascular diseases such as atherosclerosis. Bone marrow-derived endothelial progenitor cells (EPCs) play an important role in the maintenance of endothelial homeostasis and contribute to re-endothelialization of injured vessels as well as revascularization of ischemic tissues. MicroRNAs (miRNAs) have been reported to regulate EPC biological functions. In this study, we found that EPCs of atherosclerosis patients and EPCs exposed to hypoxia… CONTINUE READING
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Dysregulation of angiogenesis-related microRNAs in endo- MiR-21 targeting WWP1 suppresses EPCs proliferation

  • Q Zhang, I Kandic, MJ. Kutryk
  • Int J Clin Exp Pathol
  • 2015
1 Excerpt

Endothelial dysfunction: methods of assess- MiR-21 targeting WWP1 suppresses EPCs proliferation

  • M Butt, G Dwivedi, A Blann, O Khair, GY. Lip
  • Int J Clin Exp Pathol
  • 2015
1 Excerpt

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