MiR-21 Induced Angiogenesis through AKT and ERK Activation and HIF-1α Expression

@inproceedings{Liu2011MiR21IA,
  title={MiR-21 Induced Angiogenesis through AKT and ERK Activation and HIF-1α Expression},
  author={Ling-zhi Liu and Chongyong Li and Qi Chen and Yi Jing and Richard L. Carpenter and Yue Jiang and Hsiang-fu Kung and Lihui Lai and Bing-Hua Jiang},
  booktitle={PloS one},
  year={2011}
}
MicroRNAs (miRNAs) are endogenous, small noncoding RNAs that play important roles in various cellular functions and tumor development. Recent studies have indicated that miR-21 is one of the important miRNAs associated with tumor growth and metastasis, but the role and molecular mechanism of miR-21 in regulating tumor angiogenesis remain to be elucidated. In this study, miR-21 was overexpressed by transfecting pre-miR-21 into human prostate cancer cells and tumor angiogenesis was assayed using… CONTINUE READING
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