MiR-195, miR-196b, miR-181c, miR-21 expression levels and O-6-methylguanine-DNA methyltransferase methylation status are associated with clinical outcome in glioblastoma patients.

@article{Lakom2011MiR195MM,
  title={MiR-195, miR-196b, miR-181c, miR-21 expression levels and O-6-methylguanine-DNA methyltransferase methylation status are associated with clinical outcome in glioblastoma patients.},
  author={Radek Lakomỳ and Jiri Sana and Simona Hankeova and Pavel Fadrus and Leo{\vs} Křen and Eva L{\vz}i{\vc}ařov{\'a} and Marek Svoboda and Hana Dole{\vz}elov{\'a} and Martin Smr{\vc}ka and Rostislav Vyzula and Jaroslav Mich{\'a}lek and Mari{\'a}n Hajd{\'u}ch and Ondrej Slaby},
  journal={Cancer science},
  year={2011},
  volume={102 12},
  pages={2186-90}
}
Glioblastoma multiforme (GBM) is the most frequently occurring primary malignant brain tumor; patients with GBM often have a very poor prognosis and differing responses to treatment. Therefore, it is very important to find new biomarkers that can predict clinical outcomes and help in treatment decisions. MicroRNAs are small, non-coding RNAs that function as post-transcriptional regulators of gene expression and play a key role in the pathogenesis of GBM. In a group of 38 patients with primary… CONTINUE READING

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