• Corpus ID: 207763950

MiR-19 a affects hepatocyte autophagy via regulating lncRNA NBR 2 and AMPK / PPARα in D-GalN / lipopolysaccharide-stimulated hepatocytes † Running title : miR-19 a regulates hepatocyte autophagy

@inproceedings{Liu2017MiR19AA,
  title={MiR-19 a affects hepatocyte autophagy via regulating lncRNA NBR 2 and AMPK / PPAR$\alpha$ in D-GalN / lipopolysaccharide-stimulated hepatocytes † Running title : miR-19 a regulates hepatocyte autophagy},
  author={Yanmin Liu and Jin-Hui Ma and Qing-Lei Zeng and Jun Lv and Xuhua Xie and Ya-Jie Pan and Zu-Jiang Yu},
  year={2017}
}
No Paper Link Available

Figures from this paper

References

SHOWING 1-10 OF 25 REFERENCES
Induction of apoptosis and autophagy via mitochondria- and PI3K/Akt/mTOR-mediated pathways by E. adenophorum in hepatocytes of saanen goat
TLDR
The study has shown that the typical apoptotic features, the increasing apoptotic hepatocytes and activated caspase-9, −3 and the subsequent cleavage of PARP indicated the potent pro-apoptotic effects of E. adenophorum.
Inhibition of caspase-9 aggravates acute liver injury through suppression of cytoprotective autophagy
TLDR
Treatment with caspase-9 inhibitor z-LEHD-FMK in HepG2 cells, AML12 cells and C57BL/b6N mice exacerbated CCl4-induced acute hepatocellular damage, and also down-regulated autophagy markers expression levels, indicating that casp enzyme-9 inhibition may aggravate acute liver damage by suppressing cytoprotective Autophagy.
Myocardial Ischemic Postconditioning Promotes Autophagy against Ischemia Reperfusion Injury via the Activation of the nNOS/AMPK/mTOR Pathway
TLDR
IPostC promoted autophagy against I/R injury at least partially via the activation of nNOS/AMPK/mTOR pathway, and autophagic activity was raised markedly.
Qingchangligan formula attenuates the inflammatory response to protect the liver from acute failure induced by d-galactosamine/lipopolysaccharide in mice.
The role of microRNAs in liver injury at the crossroad between hepatic cell death and regeneration.
Vitexin alleviates ox‐LDL‐mediated endothelial injury by inducing autophagy via AMPK signaling activation
ANT2 shRNA downregulates miR-19a and miR-96 through the PI3K/Akt pathway and suppresses tumor growth in hepatocellular carcinoma cells
TLDR
The results suggest that ANT2-regulatedmiR-19a and miR-96 play an important role in promoting the proliferation of human HCC cells, and the knockdown of AnT2 directly downregulates miR, 19a and 96, ultimately resulting in the suppression of tumor growth.
Autophagy inhibition of hsa-miR-19a-3p/19b-3p by targeting TGF-β R II during TGF-β1-induced fibrogenesis in human cardiac fibroblasts
TLDR
This study uncovers a novel mechanism that miR-19a-3p/19b-3P inhibits autophagy-mediated fibrogenesis by targeting TGF-β R II.
Inhibition of glycogen synthase kinase 3beta promotes autophagy to protect mice from acute liver failure mediated by peroxisome proliferator-activated receptor alpha
  • Cell death 7:e2151
  • 2016
NBR2: A former junk gene emerges as a key player in tumor suppression
TLDR
It is shown that NBR2 encodes a long non-coding RNA and suppresses tumor development through regulation of adenosine monophosphate–activated protein kinase (AMPK) activation.
...
1
2
3
...