MiR-17-92 cluster is associated with 13q gain and c-myc expression during colorectal adenoma to adenocarcinoma progression

@article{Diosdado2009MiR1792CI,
  title={MiR-17-92 cluster is associated with 13q gain and c-myc expression during colorectal adenoma to adenocarcinoma progression},
  author={Begoňa Diosdado and Mark A. van de Wiel and Jochim S. Terhaar sive Droste and Sandra Mongera and Cindy Postma and W J H J Meijerink and Beatriz Carvalho and G A Meijer},
  journal={British Journal of Cancer},
  year={2009},
  volume={101},
  pages={707 - 714}
}
Background:MicroRNAs are small non-coding RNA molecules, which regulate central mechanisms of tumorigenesis. In colorectal tumours, the combination of gain of 8q and 13q is one of the major factors associated with colorectal adenoma to adenocarcinoma progression. Functional studies on the miR-17-92 cluster localised on 13q31 have shown that its transcription is activated by c-myc, located on 8q, and that it has oncogenic activities. We investigated the contribution of the miR-17-92 cluster… CONTINUE READING

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