MiR-155-mediated loss of C/EBPβ shifts the TGF-β response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer

@inproceedings{Johansson2013MiR155mediatedLO,
  title={MiR-155-mediated loss of C/EBPβ shifts the TGF-β response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer},
  author={J{\"o}rgen Johansson and Tove Berg and Ewa Kurzejamska and M-F Pang and Vedrana Tabor and Michael Jansson and Pernilla Roswall and Kristian Pietras and Malin Sund and Piotr Religa and Jonas Fuxe},
  booktitle={Oncogene},
  year={2013}
}
During breast cancer progression, transforming growth factor-beta (TGF-β) switches from acting as a growth inhibitor to become a major promoter of epithelial-mesenchymal transition (EMT), invasion and metastasis. However, the mechanisms involved in this switch are not clear. We found that loss of CCAAT-enhancer binding protein beta (C/EBPβ), a differentiation factor for the mammary epithelium, was associated with signs of EMT in triple-negative human breast cancer, and in invasive areas of… CONTINUE READING
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Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2012

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