MiR-155 is a liposarcoma oncogene that targets casein kinase-1α and enhances β-catenin signaling.

  title={MiR-155 is a liposarcoma oncogene that targets casein kinase-1α and enhances β-catenin signaling.},
  author={Pingyu Zhang and Katelynn Bill and Juehui Liu and Eric Patrick Young and Tingsheng Peng and Svetlana Bolshakov and Aviad Hoffman and Yechun Song and Elizabeth G Demicco and Dolores Lopez Terrada and Chad J Creighton and Matthew L Anderson and Alexander J F Lazar and George G. Calin and Raphael E Pollock and Dina Chelouche Lev},
  journal={Cancer research},
  volume={72 7},
Liposarcoma can be an aggressive, debilitating, and fatal malignancy. In this study, we identifed miRNAs associated with the differentiation status of liposarcoma to gain insight into the basis for its progression. miRNA expression profiles determined in human tumors and normal fat specimens identified a dedifferentiated tumor expression signature consisting of 35 miRNAs. Deregulated miRNA expression was confirmed in a second independent sample cohort. The miR-155 was the most overexpressed… CONTINUE READING


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  • S Vijayakumar, G Liu, A Rus Ioana, S Yao, Y Chen, G Akiri
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