MiR-150 promotes gastric cancer proliferation by negatively regulating the pro-apoptotic gene EGR2.

@article{Wu2010MiR150PG,
  title={MiR-150 promotes gastric cancer proliferation by negatively regulating the pro-apoptotic gene EGR2.},
  author={Qiong Wu and Haifeng Jin and Zhiping Yang and Guanhong Luo and Yuanyuan Lu and Kai Li and Gui Ren and Tao Su and Yan Pan and Bin Feng and Zengfu Xue and Xin Wang and Dai-ming Fan},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={392 3},
  pages={340-5}
}
Accumulating evidence suggests small non-coding RNAs (microRNAs) play important roles in human cancer progression. In the present study, we found miR-150 was overexpressed in gastric cancer cell lines and tissues. Ectopic expression of miR-150 promoted tumorigenesis and proliferation of gastric cancer cells. Luciferase reporter assay demonstrated that EGR2 was a direct target of miR-150. Collectively, our study demonstrated that overexpression of miR-150 in gastric cancer could promote… CONTINUE READING

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