MiR-148a Attenuates Paclitaxel Resistance of Hormone-refractory, Drug-resistant Prostate Cancer PC3 Cells by Regulating MSK1 Expression*

@article{Fujita2010MiR148aAP,
  title={MiR-148a Attenuates Paclitaxel Resistance of Hormone-refractory, Drug-resistant Prostate Cancer PC3 Cells by Regulating MSK1 Expression*},
  author={Yasunori Fujita and Keitarou Kojima and Riyako Ohhashi and Nanako Hamada and Yoshinori Nozawa and Aya Kitamoto and Akira Sato and Shinji Kondo and Toshio Kojima and Takashi Deguchi and Masafumi Ito},
  journal={The Journal of Biological Chemistry},
  year={2010},
  volume={285},
  pages={19076 - 19084}
}
MicroRNAs are involved in cancer pathogenesis and act as tumor suppressors or oncogenes. It has been recently reported that miR-148a expression is down-regulated in several types of cancer. The functional roles and target genes of miR-148a in prostate cancer, however, remain unknown. In this report, we showed that miR-148a expression levels were lower in PC3 and DU145 hormone-refractory prostate cancer cells in comparison to PrEC normal human prostate epithelial cells and LNCaP hormone… 
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MicroRNAs (miRs) are a class of non-coding RNAs that function as key regulators of gene expression at the post-transcriptional level. miR-148a has been suggested to be associated with human ovarian
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TLDR
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miR-148b reverses cisplatin-resistance in non-small cell cancer cells via negatively regulating DNA (cytosine-5)-methyltransferase 1(DNMT1) expression
TLDR
miR-148b reverses cisplatin-resistance in non-small cell cancer cells via negatively regulating DNMT1 expression and over-expressedDNMT1 reverses pro-apoptosis effect of miR- 148b mimic.
Up-regulation of miR-877 induced by paclitaxel inhibits hepatocellular carcinoma cell proliferation though targeting FOXM1.
TLDR
Results indicate that miR-877 could influence the sensitivity of paclitaxel treatment in hepatocellular carcinoma cell lines by targeting FOXM1.
MicroRNA-148a inhibits migration and invasion of ovarian cancer cells via targeting sphingosine-1-phosphate receptor 1.
TLDR
It was hypothesized that miR‑148a may potentially be used as a molecular agent for the prevention and treatment of invasion and metastasis in ovarian cancer, while S1PR1 may present a promising target for clinical applications.
microRNA-148a suppresses human gastric cancer cell metastasis by reversing epithelial-to-mesenchymal transition
TLDR
The SMAD2 gene was identified as the direct and functional target of miR-148a and suppresses gastric cancer metastasis and EMT, likely viaSMAD2.
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