MiR-145 acts as a metastasis suppressor by targeting metadherin in lung cancer.

  title={MiR-145 acts as a metastasis suppressor by targeting metadherin in lung cancer.},
  author={Mingzhi Wang and Jianhua Wang and Jianming Deng and Xuejun Li and Weiguang Long and Yongmei Chang},
  journal={Medical oncology},
  volume={32 1},
MiR-145 has been reported to be downregulated in multiple tumors. It acts as a tumor suppressor in lung cancer. In this study, we investigated the potential effects of miR-145 on invasion and metastasis and the molecular mechanism in non-small cell lung cancer. MiR-145 was downregulated in the NSCLC specimens and significantly correlated with advanced clinical stage and lymph node metastasis. In addition, AEG-1/MTDH was a direct target of miR-145, and the expression of AEG-1/MTDH was inversely… CONTINUE READING
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