MiR-135b is a direct PAX6 target and specifies human neuroectoderm by inhibiting TGF-β/BMP signaling.

@article{Bhinge2014MiR135bIA,
  title={MiR-135b is a direct PAX6 target and specifies human neuroectoderm by inhibiting TGF-β/BMP signaling.},
  author={Akshay Bhinge and Jeremie Poschmann and Seema C. Namboori and Xianfeng Tian and Sharon Jia Hui Loh and Anna Traczyk and Shyam Prabhakar and Lawrence Walter Stanton},
  journal={The EMBO journal},
  year={2014},
  volume={33 11},
  pages={1271-83}
}
Several transcription factors (TFs) have been implicated in neuroectoderm (NE) development, and recently, the TF PAX6 was shown to be critical for human NE specification. However, microRNA networks regulating human NE development have been poorly documented. We hypothesized that microRNAs activated by PAX6 should promote NE development. Using a genomics… CONTINUE READING