MiR-133b ameliorates axon degeneration induced by MPP(+) via targeting RhoA.

  title={MiR-133b ameliorates axon degeneration induced by MPP(+) via targeting RhoA.},
  author={Mengyue Niu and Renshi Xu and Jianpeng Wang and Binghui Hou and Anmu Xie},
Increasing evidence suggests that microRNAs (miRs) play a significant role in the pathogenesis of Parkinson's disease (PD). MiR-133b, which is significantly decreased in the PD midbrain, has recently been shown to promote neurite outgrowth and enhance neural functional recovery. However, the role of miR-133b in PD has not been clearly established. Here, using a well-established PD model culture based on the neurotoxin 1-methyl-4-phenyl-pyridinium (MPP(+)), we demonstrated that miR-133b could… CONTINUE READING
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