MiR-130a, miR-203 and miR-205 jointly repress key oncogenic pathways and are downregulated in prostate carcinoma

@article{Boll2013MiR130aMA,
  title={MiR-130a, miR-203 and miR-205 jointly repress key oncogenic pathways and are downregulated in prostate carcinoma},
  author={Kerstin Boll and Kristin Reiche and Katharina Kasack and Nora Moerbt and Antje Karen Kretzschmar and Janina Melanie Tomm and Gerald W Verhaegh and Jack A Schalken and Martin von Bergen and Friedemann Horn and J{\"o}rg Hackerm{\"u}ller},
  journal={Oncogene},
  year={2013},
  volume={32},
  pages={277-285}
}
With ∼30 000 deaths annually in the United States, prostate cancer (PCa) is a major oncologic disease. Here we show that the microRNAs miR-130a, miR-203 and miR-205 jointly interfere with the two major oncogenic pathways in prostate carcinoma and are downregulated in cancer tissue. Using transcriptomics we show that the microRNAs repress several gene products known to be overexpressed in this cancer. Argonaute 2 (AGO2) co-immunoprecipitation, reporter assays and western blot analysis… CONTINUE READING
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