MiR-1297 regulates the growth, migration and invasion of colorectal cancer cells by targeting cyclo-oxygenase-2.

@article{Chen2014MiR1297RT,
  title={MiR-1297 regulates the growth, migration and invasion of colorectal cancer cells by targeting cyclo-oxygenase-2.},
  author={Pu Chen and Bei-Li Wang and Bai-shen Pan and Wei Guo},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  year={2014},
  volume={15 21},
  pages={9185-90}
}
Cyclo-oxygenase-2(Cox-2), a key regulator of inflammation-producing prostaglandins, promotes cell proliferation and growth. Therefore, a better understanding of the regulatory mechanisms of Cox-2 could lead to novel targeted cancer therapies. MicroRNAs are strongly implicated in colorectal cancer but their specific roles and functions have yet to be fully elucidated. MiR-1297 plays an important role in lung adenocarcinoma and laryngeal squamous cell carcinoma, but its significance in colorectal… CONTINUE READING