MiR-129 regulates growth and invasion by targeting MAL2 in papillary thyroid carcinoma.

@article{Gao2018MiR129RG,
  title={MiR-129 regulates growth and invasion by targeting MAL2 in papillary thyroid carcinoma.},
  author={Xuejun Gao and Zhenyu Chen and Aiqin Li and Xin Zhang and Xia Cai},
  journal={Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year={2018},
  volume={105},
  pages={
          1072-1078
        }
}
  • Xuejun Gao, Zhenyu Chen, +2 authors Xia Cai
  • Published 1 September 2018
  • Medicine, Biology
  • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
MAL2, a member of the MAL proteolipid family, is essential for raft-mediated transport. In this study, we investigated the roles and underlying mechanism of MAL2 in the development of papillary thyroid carcinoma (PTC). Up-regulation of MAL2 was found in human PTC tissues and significantly correlated with poor overall survival (OS). Knockdown of MAL2 dramatically suppressed PTC cell proliferation and invasion in vitro and inhibited tumor growth in vivo. We further found that miR-129 suppressed… 
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