MiR-129 regulates growth and invasion by targeting MAL2 in papillary thyroid carcinoma.

@article{Gao2018MiR129RG,
  title={MiR-129 regulates growth and invasion by targeting MAL2 in papillary thyroid carcinoma.},
  author={Xuejun Gao and Zhenyu Chen and Aiqin Li and Xin Zhang and Xia Cai},
  journal={Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year={2018},
  volume={105},
  pages={
          1072-1078
        }
}
  • Xuejun Gao, Zhenyu Chen, +2 authors Xia Cai
  • Published 1 September 2018
  • Medicine, Biology
  • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
MAL2, a member of the MAL proteolipid family, is essential for raft-mediated transport. In this study, we investigated the roles and underlying mechanism of MAL2 in the development of papillary thyroid carcinoma (PTC). Up-regulation of MAL2 was found in human PTC tissues and significantly correlated with poor overall survival (OS). Knockdown of MAL2 dramatically suppressed PTC cell proliferation and invasion in vitro and inhibited tumor growth in vivo. We further found that miR-129 suppressed… 
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References

SHOWING 1-10 OF 35 REFERENCES
MicroRNA-613 inhibits cell growth, migration and invasion of papillary thyroid carcinoma by regulating SphK2
TLDR
The results indicated that miR-613 functions as a tumor suppressor in PTC and its suppressive effect is mediated by repressing SphK2 expression.
miR-29a suppresses growth and migration of hepatocellular carcinoma by regulating CLDN1.
TLDR
Out data suggested that miR-29a may regulate tumor growth and migration by targeting CLDN1, providing promising therapeutic targets for HCC.
MiR‐129‐5p is down‐regulated and involved in the growth, apoptosis and migration of medullary thyroid carcinoma cells through targeting RET
TLDR
It is demonstrated that miR‐129‐5p is down‐regulated in MTC tissues and cell lines and inhibits RET expression by directly binding its 3′ untranslated regions, thus functioning as a tumor suppressor.
Down-Regulation of miR-129-5p Inhibits Growth and Induces Apoptosis in Laryngeal Squamous Cell Carcinoma by Targeting APC
TLDR
The results suggest miR-129-5p functions as an oncogene in LSCC by repressing APC and is a potential therapeutic target for LSCC.
miR-129 promotes apoptosis and enhances chemosensitivity to 5-fluorouracil in colorectal cancer
TLDR
The discovery of a novel mechanism mediated by microRNA-129 (miR-129) to trigger apoptosis by suppressing a key anti-apoptotic protein, B-cell lymphoma 2 (BCL2) is discovered and it is demonstrated that miR- 129 enhanced the cytotoxic effect of 5-fluorouracil both in vitro and in vivo.
MicroRNA-137 inhibits BMP7 to enhance the epithelial-mesenchymal transition of breast cancer cells
TLDR
Light is shed on miR-137 as a crucial factor that enhances BC cell EMT and invasiveness, and it is pointed to as a promising innovative therapeutic target for BC treatment.
MicroRNA-124 inhibits proliferation, invasion, migration and epithelial-mesenchymal transition of cervical carcinoma cells by targeting astrocyte-elevated gene-1.
TLDR
Findings suggested that miR-124 was able to suppress cell proliferation, invasion and migration, as well as the EMT process in cervical carcinomas through directly targeting AEG-1.
MiR-137 and miR-34a directly target Snail and inhibit EMT, invasion and sphere-forming ability of ovarian cancer cells
TLDR
E ectopic expression of Snail significantly reversed the inhibitory effects ofmiR-137 and miR-34a on OC cell invasion and sphere formation, and suggest that both miR -137 andMiR -34a act as Snail suppressors to negatively regulate EMT, invasive and sphere-forming properties of OC cells.
miR-124 suppresses glioblastoma growth and potentiates chemosensitivity by inhibiting AURKA.
TLDR
It is demonstrated that miR-124 inhibited glioblastoma growth and potentiated chemosensitivity by targeting AURKA, which may represent promising targets and rational therapeutic options for gliOBlastoma.
MicroRNA-29b regulates TGF-β1-mediated epithelial-mesenchymal transition of retinal pigment epithelial cells by targeting AKT2.
TLDR
Data indicate that miR-29b plays an important role in TGF-β1-mediated EMT in ARPE-19 cells by targeting Akt2, which is characterized by the phenotypic transition and the upregulation of α-smooth muscle actin and downregulation of E-cadherin and zona occludin-1 with increased cell migration.
...
1
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3
4
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