MiR-125a promotes paclitaxel sensitivity in cervical cancer through altering STAT3 expression

  title={MiR-125a promotes paclitaxel sensitivity in cervical cancer through altering
STAT3 expression},
  author={Zusen Fan and Hairong Cui and H Yu and Qing-Hai Ji and Liang Kang and Baohui Han and Jinxia Wang and Qiong Dong and Y Li and Zhifeng Yan and Xiaomei Yan and Xi-ping Zhang and Zhenxing Lin and Yaqi Hu and Shun Chang Jiao},
Cervical cancer (CC) is one of the most common malignancies in women. Paclitaxel is the front-line chemotherapeutic agent for treating CC. However, its therapeutic efficacy is limited because of chemoresistance, the mechanism of which remains poorly understood. Here, we used microRNA (miRNA) arrays to compare miRNA expression levels in the CC cell lines, HeLa and CaSki, with their paclitaxel resistance counterparts, HeLa/PR and CaSki/PR. We demonstrate that miR-125a was one of most… CONTINUE READING
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