MiR-124 Suppresses Growth of Human Colorectal Cancer by Inhibiting STAT3

@inproceedings{Zhang2013MiR124SG,
  title={MiR-124 Suppresses Growth of Human Colorectal Cancer by Inhibiting STAT3},
  author={Ju-feng Zhang and Yanxin Lu and Xupeng Yue and Huiming Li and Xia Luo and Ying Wang and Kepeng Wang and Jun Wan},
  booktitle={PloS one},
  year={2013}
}
Emerging evidence indicate that microRNAs (miRNAs) may play important roles in cancer. Aberrant expression of miRNAs has been frequently identified in different human malignancies, including colorectal cancer (CRC). However, the mechanism by which deregulated miRNAs impact the development of CRC remains largely elusive. In this study, we show that miR-124 is significantly down-regulated in CRC compared to adjacent non-tumor colorectal tissues. MiR-124 suppresses the expression of STAT3 by… CONTINUE READING