MiR-106a inhibits glioma cell growth by targeting E2F1 independent of p53 status

@article{Yang2011MiR106aIG,
  title={MiR-106a inhibits glioma cell growth by targeting E2F1 independent of p53 status},
  author={Guang Yang and Ruyou Zhang and Xiaofeng Chen and Yulong Mu and Jing Ai and Chen Shi and Yaohua Liu and Changbin Shi and Lihua Sun and Nikolai G. Rainov and Hulun Li and Baofeng Yang and Shiguang Zhao},
  journal={Journal of Molecular Medicine},
  year={2011},
  volume={89},
  pages={1037-1050}
}
MicroRNAs are single-stranded small non-coding RNA molecules which regulate mammalian cell growth, differentiation, and apoptosis by altering the expression of other genes and play a role in tumor genesis and progression. MiR-106a is upregulated in several types of malignancies and provides a pro-tumorigenic effect. However, its role in glioma is largely unknown. Our findings demonstrate that the low expression of miR-106a in human glioma specimens is significantly correlated with high levels… CONTINUE READING
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