MgADP promotes a catch-like state developed through force-calcium hysteresis in tonic smooth muscle.

@article{Khromov1998MgADPPA,
  title={MgADP promotes a catch-like state developed through force-calcium hysteresis in tonic smooth muscle.},
  author={Alexander S. Khromov and Avril V. Somlyo and Andrew P. Somlyo},
  journal={Biophysical journal},
  year={1998},
  volume={75 4},
  pages={1926-34}
}
Tonic rabbit femoral artery and phasic rabbit ileum smooth muscles permeabilized with Triton X-100 were activated either by increasing [Ca2+] from pCa > 8.0 to pCa 6.0 (calcium-ascending protocol) or contracted at pCa 6.0 before lowering [Ca2+] (calcium-descending protocol). The effects of, respectively, high [MgATP]/low [MgADP] [10 mM MgATP + creatine phosphate (CP) + creatine kinase (CK)] or low [MgATP]/[MgADP] (2 mM MgATP, 0 CP, 0 CK) on the "force-[Ca]" relationships were determined. In… CONTINUE READING
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